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4th June 2019
10:00 to 10:10 Welcome and Introduction Jane Leeks (Newton Gateway to Mathematics)
David Abrahams (University of Cambridge)
Session 1: Chaired by Pras Pathmanathan (U. S. Food and Drug Administration)
10:10 to 10:30 Introduction Gary Mirams (University of Nottingham)
10:30 to 10:55 Clinical Applications of Cardiac Models Steven Niederer (King's College London)
10:55 to 11:20 The Role of Constraints in Metabolic Flux Analysis: Applications to Mitochondria in Cardiovascular Disease Anna Sher (GlaxoSmithKline)
11:20 to 11:40 Tea and coffee
Session 2: Chaired by Kylie Beattie (GlaxoSmithKline)
11:40 to 12:05 Modelling and Simulation for Medical Devices: When Can we Trust a Computational Model? Pras Pathmanathan (U. S. Food and Drug Administration (FDA))
12:05 to 12:30 From Medical Images to Digital Twins: Technological and Translational Challenges Tiziano Passerini (Siemens Healthineers)
12:30 to 12:55 Numerical Solution Methods for the Heart and the Circulation Alfio Quarteroni (EPFL - Ecole Polytechnique Fédérale de Lausanne), (Politecnico di Milano)
12:55 to 13:55 Lunch
Session 3: Chaired by Anna Sher (Pfizer)
13:55 to 14:20 Cardiac Electrophysiology Modelling for Cardiac Safety Assessment Kylie Beattie (GlaxoSmithKline)
14:20 to 14:45 The Living Heart Project: Development of Multi-scale Computational Heart Models with Applications in Individualised Cardiovascular Care Clint Davies-Taylor (Dassault Systémes)
14:45 to 15:10 Enhanced Methods for Diagnosing Pharmacometric Models: Random Sampling from Conditional Distributions Benjamin Ribba (Roche Pharmaceuticals )
15:10 to 15:30 Tea and coffee
Session 4: Chaired by Gary Mirams (University of Nottingham)
15:30 to 15:55 Sensitivity and Uncertainty Analysis for Cardiac Cell Models Richard Clayton (University of Sheffield)
15:55 to 16:20 Model Order Reduction by Congruency Training in Simulations of Cardiac Mechanics Viatcheslav Gurev (IBM Research)
16:20 to 16:45 Pharmacokinetic-Pharmacodynamic Modelling to Translate Cardiovascular Pharmacology from Preclinical Findings to the Clinic in Drug Development Piet van der Graaf (Certara)
16:45 to 17:00 Q&A and Close Gary Mirams (University of Nottingham)
17:00 to 18:00 Drinks and Networking Reception